Located on a hilltop, Six Senses is in the Douro Valley, Portugal’s celebrated wine region. The striking terracotta-hued 19th-century manor is all about well-being: From river-view rooms to ancient trees in the grounds’ nature trails. This luxurious 5* resort offers its guests a variety of amenities, such as an outdoor infinity pool, and a state-of-the-art Spa facility. The 71 rooms and suites come with panoramic river views and floor-to-ceiling windows. Carefully decorated rooms have been designed to respect the natural surroundings. Guests can also enjoy the organic produce from the kitchen’s own gardens and taste the finest wines of the region at the Wine Library.